Known as Bypass Road, the state highway runs 1.09 miles (1.75 km) from a dead end adjacent to the junction of U.S. Route 13 (US 13) and US 113 north to MD 756 within Pocomoke City.

MD 359 begins at a dead end adjacent to Worcester Post 93 of the American Legion.

[2] The state highway heads north as a two-lane undivided road and meets American Legion Drive (unsigned MD 359B), which provides access to US 113 near its southern terminus at US 13.

The state highway reaches its northern terminus at an oblique intersection with MD 756 (Old Snow Hill Road), a short distance west of MD 756's end at US 113.

The first alignment, to which US 113 was assigned in 1927, began at US 13 (now US 13 Business) within the city limits, following Sixth Street and Linden Avenue to the western end of what is now MD 756.