Masaka Secondary School is a mixed, day and boarding middle and high school, located in Masaka District, in Central Uganda.And also its a Muslim school which teaches Arabic though it also welcomes non Muslims The school campus is situated in the city of Masaka in Kimaanya-Kyabakuza Division , Masaka District, approximately 138 kilometres (86 mi) west of Kampala, the capital of Uganda, and the largest city in that country.

[1] The campus is located to the immediate southwest of the central business district of Masaka.

The first headteacher of the School was Mr. Stephen Kerr, it has had a number of prominent headteachers in the country including Ali Ssendagire and Lubega Waggwa.

In 2012, it received a grant of US$2 million (UGX:5 billion), from the African Development Bank, in collaboration with the Uganda Government, to construct new classrooms, a computer center, a library and new science laboratories.

[3] Notable alumni of Masaka Secondary School include the following:[4]