It was accredited by the Uganda National Council for Higher Education in 2007[3] and chartered in March 2024.

[6] The second campus is on Mengo Hill, the seat of the Buganda Government, within the city of Kampala.

The third campus is in the town of Mubende, approximately 153 kilometres (95 mi), by road, west of Kampala.

[7] MRU was established when ownership of the Masaka Technical Institute (also known as the Uganda Technical College, Masaka), was transferred from the government of Uganda to the Buganda government in January 2007.

At the same ceremony, Ronald Muwenda Mutebi was installed as the first chancellor of the university.