[2] The municipality has smaller villages such as Tecuani and La Plata, both a couple miles away.

[3] In prehispanic times, Mascota was the head of a cacicazgo, which ruled over the populations of Talpa, El Tuito and Chacala.

[2] In 1525, the Spanish explorer Francisco Cortés de San Buenaventura arrived to Mascota, who was commanded by Hernán Cortés to conquer the provinces north of Colima, which was subsequently renamed to "Valle de Banderas".

[2][4] 10 years after, in 1535, a rebellion of indigenous people was held in Mascota, along with other villages nearby.

On 10 April 1885, Villa de Mascota received the title of city.