Matetsi is a village in Matabeleland North Province, Zimbabwe, located about 55 km west of Hwange.

The nearest airports are Victoria Falls (Zimbabwe), Kasane (Botswana), and Harry Mwaanga Nkumbula (Zambia).

The Matetsi Safari Area is one of the largest hunting complexes in Zimbabwe, consisting of 7 separate concessions, covering 3,000 km2 (1,200 sq mi) in total.

The area reaches from the Zambezi River in the north to Hwange National Park in the south.

Within the reserve, close to the Zambezi River, there is a luxury accommodation called Matetsi Victoria Falls.