During the 1990s, the Matrox Millennium series of cards attracted buyers willing to pay for a higher quality and sharper display.

A later version of the Millennium included features similar to the Impression but by this time the series was lagging behind emerging vendors like 3dfx Interactive.

The Matrox Mystique, released in 1996, was the company's first attempt to make a card with good performance in games and with pricing suitable for that market.

The product had good 2D and 3D performance but produced poor 3D images with the result that it was derided in reviews, being compared unfavorably with the Voodoo1 and even being nicknamed the "Matrox Mystake".

The G200 offered competent 3D performance for the first time, but was released shortly before a new generation of cards from Nvidia and ATI which completely outperformed it.

Since then, Matrox has continued to shift the focus of its card designs towards specialized, niche markets, moving more deeply into enterprise, industrial, and government applications.