Maurice Nicolle (1 March 1862 – 20 August 1932) was a French physician and microbiologist born in Rouen.
In 1890 he supported his doctorate with a thesis on a study of diseases of the myocardium, titled Contribution à l'étude des affections du myocarde: les grandes scléroses cardiaques.
At the Pasteur Institute he performed investigations on hypersensitivity and immunity (action of antibodies, antigens and antitoxins) following inoculations of glanders bacilli into guinea pigs.
From 1906 with zoologist Felix Mesnil (1868–1938), he tested benzopurpurine dyes supplied by Bayer Pharmaceutical as trypanocidal agents for destruction of the parasite associated with trypanosomiasis.
[1] In 1910 he succeeded Jean Binot (1867–1909) as laboratory head of microbiology courses at the Pasteur Institute.