[1] In addition to her high school playing experience, Zerboni was an Olympic Development Program (ODP) State and Region-IV team member and played club soccer for the Southern California Blues for several years, helping them to League Cup Championships in 2001 and 2002, a Region-IV Championship in 2000 and their first-ever Surf Cup title in 2004.

Zerboni became the 16th player in UCLA history to register a hat trick in a 5–0 victory over Fresno State in the first round of the 2008 NCAA Tournament.

[4] After the WPS folded in early 2012, Zerboni played for the Western New York Flash in the Women's Premier Soccer League Elite as the team captain.

In January 2013, the Western New York Flash announced that Zerboni would return to the team its inaugural season of the National Women's Soccer League.

[7] The Portland Thorns FC acquired Zerboni in a trade alongside Kathryn Williamson in exchange for midfielder Amber Brooks on November 6, 2014 in an attempt to give the team more available full-time players for the coming 2015 season, during which the Thorns anticipated needing to fill in for players called up to the national team to participate in the 2015 FIFA Women's World Cup.

On October 26, 2015, Boston Breakers announced that they had obtained Zerboni from Portland Thorns FC in a package deal along with Sinead Farrelly for first-round (No.

She made a successful return on June 8, 2024 in a home game against Angel City FC, coming on in the 77th minute and assuming the captain’s armband.

She made her debut as a halftime substitute against South Korea on October 22, 2017,[15] making her the oldest player to earn a first cap for the U.S. women's national team at two months shy of her 31st birthday.

Zerboni suffered a broken elbow in a friendly against Chile on September 4, making her unavailable for the 2018 CONCACAF Women's Championship.