The McKenzie Pass–Santiam Pass Scenic Byway is an 82-mile-long (132 km) National Scenic Byway in the U.S. state of Oregon.

The route begins on its eastern end at the town of Sisters in northern Deschutes County.

It follows Oregon Route 126 westward over Santiam Pass south of Three Fingered Jack, then south along the valley of the McKenzie River.

The route is considered a summer tour route, since the road over McKenzie Pass is closed in winter due to snowfall.

It was later made an Oregon State Scenic Byway on February 19, 1997 before becoming a National Scenic Byway on June 9, 1998.