Meadow Run is a 14.23 mi (22.90 km) long 4th order tributary to the Youghiogheny River in Fayette County, Pennsylvania.

According to the Geographic Names Information System, it has also been known historically as:[1] Meadow Run rises about one mile (2 km) northeast of Washington Springs, Pennsylvania,[2] and then flows southeast and northeast to join the Youghiogheny River at Ohiopyle.

[3] Meadow Run drains 41.20 square miles (106.7 km2) of area, receives about 50.7 in (1,290 mm) per year of precipitation, has a wetness index of 376.51, and is about 82% forested.

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