[1] It is also used in the treatment of torsades de pointes, severe asthma exacerbations, constipation, and barium poisoning.

Epsom salt baths have been claimed to also soothe and hasten recovery of muscle pain, soreness, or injury.

[15] The solubility of magnesium sulfate water is inhibited by lipids in lotions resulting in variable absorption rates when applied to the skin.

[17] Magnesium sulfate is commonly used in flotation therapy to prepare the concentrated solutions that fill the isolation tanks.

[18] In the United Kingdom, a medication containing magnesium sulfate, called "drawing paste", is claimed to be useful for small boils or localised infections,[19] and removing splinters.

[20] The standard British Pharmacopoeia composition is dried magnesium sulfate 47.76% (by mass), phenol 0.49%, and glycerol to balance.

Magnesium sulfate may be used as an antiarrhythmic agent for torsades de pointes in cardiac arrest under the ECC guidelines and for managing quinidine-induced arrhythmias.

[22] Magnesium sulfate may be used as bronchodilator after beta-agonist and anticholinergic agents have been tried, e.g. in severe exacerbations of asthma,[23] The salt can be administered by nebulization[23] or by intravenous injection.

[32] Guidelines for the use of magnesium sulfate in mothers at risk of preterm labour are not strongly adhered to[34] and further research is needed to determine the effects of this treatment later in early childhood.