Metyrapone, sold under the brand name Metopirone, is a medication which is used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing's syndrome (hypercortisolism).

Metyrapone is used for the medical control of hypercortisolism in Cushing's syndrome (ACTH dependent or independent).

It is not for long term definitive treatment/cure, only as an adjunct (surgery is the aim for cure in most causes of Cushing's syndrome).

Metyrapone has been found in early human trials to reduce recollection of emotional memories in normal volunteers.

This has significant implication in the study of the process of emotional healing in post traumatic stress disorder.