[4] Mehlville High School was first established in 1925 after parents demanded local secondary education for their children.

[4] To handle the rapidly growing student body, the current building was built adjacent to the previous one in 1955.

It is currently home to SCOPE, an alternative education program, and some district offices, including the IT department.

The building is set to be demolished in the near future, with SCOPE and the district offices being moved elsewhere off-campus.

What will replace the Witzel Learning Center currently remains unknown, but it assumed to be used simply as an open lot for the foreseeable future.

The second level (the "Upper Commons") includes a new entrance to the main gymnasium (Gym A), a trophy hall, and 12 science classrooms with labs.

The old baseball facilities, which held numerous safety issues due to an exposed drain in center field and uneven terrain, was retired and currently sits abandoned, although the junior varsity football team occasionally uses the field for its practices.

This is a great way to express a student's interests, hobbies and creativity and to leave a lasting impact at the school.

In the school's Upper Commons, there is a wooden panther statue with a time capsule embedded inside its base.

The racial makeup of the school is approximately 72% White, 12% Black, 5% Asian, 5% Hispanic, and 6% mixed-race.

Mehlville is a cultural melting pot, influenced heavily by immigration and foreign exchange students.