Trains go east to Ogilvie Transportation Center in Chicago and as far west as Elburn, Illinois.

Travel time to Ogilvie is 23 to 29 minutes, depending on the train.

As of 2018[update], Melrose Park is the 196th busiest of the 236 non-downtown stations in the Metra system, with an average of 86 weekday boardings.

Melrose Park was originally built by the Chicago and North Western Railway and acquired by Metra.

The station is at Main Street and North 18th Avenue, in Melrose Park's business district.