Both the Memorial and Hermann health care systems started in the early 1900s.

The hospital system has been headed by some of the most influential leaders in healthcare including Dan Wolterman,[4] Dr. Benjamin K. Chu[5] as well as the current President & CEO David L. Callender, MD[6]

Dennis Pevoto who purchased an 18-bed sanitarium in downtown Houston, calling it the Baptist Sanatorium.

Prominent local businessman George H. Hermann died in 1914, leaving a large portion of his $2.6 million estate for building and maintaining a hospital for the poor and sick of Houston.

[8] The flagship Texas Medical Center hospital is home to Memorial Hermann Life Flight, an emergency and critical-care-transport aeromedical service.

In 1993 Memorial Hermann - Texas Medical Center acquired the region's first Gamma Knife.

[12] Memorial Hermann has since made efforts to rebuild the Southwest Hospital.

[14] The management Services program of Memorial Hermann Healthcare System won the 2011 Franklin Award of Distinction.

[20] 9401 Southwest Freeway has 214,000 square feet (19,900 m2) of space and, as of 2009, was owned by the Los Altos, California company Investment Grade Loans.

As of 2009 BGK of Texas owns 9301 Southwest Freeway, and that year Moody Rambin Interests became the leasing company.

[22] On July 9, 2010 the hospital system entered into a lease for over 800,000 square feet (74,000 m2) of office space with MetroNational Corp., involving the former North Tower and the Medical Office Buildings 1–4 on the Memorial City campus.