Mesodescolea is a genus of fossil foliage with uncertain affinities from the Early Cretaceous of Argentina[1] and Antarctica.

The genus was first erected by Sergio Archangelsky based on material from the Aptian of the Anfiteatro de Ticó formation.

Later reinvestigations and emendations cemented the view that Mesodescolea was a member of the Cycadales family Stangeriaceae.

[3][4][5] Other authors have proposed that the genus represents a member of the angiosperms with affinities with the ANA grade or Chloranthaceae.

Leaves of Mesodescolea are locally abundant in the deposits of the Anfiteatro de Ticó formation.