With the sequencing of complete genomes, it is now possible to reconstruct the network of biochemical reactions in many organisms, from bacteria to human.
Several of these networks are available online: Kyoto Encyclopedia of Genes and Genomes (KEGG),[1] EcoCyc,[2] BioCyc[3] and metaTIGER.
Metabolic networks can be used to detect comorbidity patterns in diseased patients.
[6] The disease phenotypes themselves are normally the consequence of the cell's inability to breakdown or produce an essential substrate.
Thus, metabolic disease networks can be used to determine if two disorders are connected due to their correlated reactions.