[5][6][7] L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors.

Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.

Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

[14] Mutations in both copies have been associated with developmental and epileptic encephalopathy, microcephaly, hypomyelination and cerebral atrophy.

[15] This article incorporates text from the United States National Library of Medicine, which is in the public domain.