[7][8] Deficits in mGluR3 signaling have been linked to impaired cognition in humans,[9] and to increased risk of schizophrenia,[10] consistent with their expanding role in cortical evolution.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors.

Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

[13] A follow-up study of the Kozak sequence variant showed that it was associated with increased risk of bipolar disorder, schizophrenia and alcoholism.

Metabotropic glutamate receptor 3 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.