[5][6] L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors.

Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.

Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

The glutamate receptor mGluR6 is located post-synaptically at the tips of the bipolar cell dendrites, and is responsible for initiating a signaling cascade that ultimately controls gating of the TRPM1 channel.

[9][10] This article incorporates text from the United States National Library of Medicine, which is in the public domain.