LY-341495 is a research drug developed by the pharmaceutical company Eli Lilly, which acts as a potent and selective orthosteric antagonist for the group II metabotropic glutamate receptors (mGluR2/3).

[1][2][3][4] It is used in scientific research in several different areas, showing antidepressant effects in animal models,[5][6][7][8] increasing the behavioural effects of hallucinogenic drugs in animal tests,[9][10][11][12] and increasing the analgesic effects of μ-opioid agonists,[13][14] as well as modulating dopamine receptor function.

[15][16][17] The 1-fluorocyclopropane analog has a superior pharmacokinetic profile and similar mGluR2/3 affinity, and making a prodrug from this with the heptyl ester increases bioavailability still further.

[18]