2QEP, 4HTI, 4HTJ579919276ENSG00000155093ENSG00000282185ENSMUSG00000056553Q92932P80560NM_001308267NM_001308268NM_002847NM_130842NM_130843NM_011215NP_001295196NP_001295197NP_002838NP_570857NP_570858NP_035345Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) also known as islet cell autoantigen-related protein (ICAAR) and phogrin is an enzyme that in humans is encoded by the PTPRN2 gene.

[5][6][7] PTPRN and PTPRN2 (this gene) are both found to be major autoantigens associated with insulin-dependent diabetes mellitus.

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

However, recent research has shown that the PTPRN2 mouse homolog, known as phogrin, dephosphorylates the lipid phosphatidylinositol rather than tyrosine.

[7] Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.