The station's pictogram features the logo of the National Polytechnic Institute (IPN), a public university in Mexico City, and its name is on account of its proximity to the main campus.

[10] The mural was inaugurated in 1996 and depicts the history of the IPN, its culture and campus life, the Once TV network logo and the image of Lázaro Cárdenas, the 51st president of Mexico and founder of the university.

[11] Line 5 of the Mexico City Metro was built by Cometro, a subsidiary of Empresas ICA,[12] and its last section was opened on 30 August 1982, operating from Pantitlán to Politécnico stations.

[17] In June 2006, Metro authorities replaced the railroad switches;[18] in 2008, they had maintenance work done on the station's roof.

[19] During the 1980s and 1990s, it was proposed to expand Line 5 northbound towards the municipality of Tlalnepantla de Baz, in the State of Mexico, from Politécnico metro station.

[26] On 8 November 2020, Politécnico, Instituto del Petróleo and Lindavista stations were vandalized during feminist demonstrations; walls, screens, handrails, a train, and part of the La técnica al servicio de la patria mural were damaged and graffitied.