In 1393, a castle at Mettenheim was mentioned, whose owners, the Chamberlains and Knights of Fleckenstein, sold it at that time to the City of Worms.

About half of the usable agricultural land of 540 ha in Mettenheim is planted with vineyards.

Mettenheim lies in the Nierstein zone of the Rhenish Hesse wine region and bears the winemaking appellations Michelsberg, Schloßberg and Goldberg.

Jacob Best, Sr. (1786–1861) was born in Hesse-Darmstadt where he learned the brewing trade, later running a small brewery in Mettenheim.

He later founded one of the forerunners of the Pabst Brewing Company in Milwaukee after his emigration in 1844 to join his sons.