Westhofen lies between Worms (roughly 12 km to the southeast), Mainz and Alzey in Rhenish Hesse and is part of the Verbandsgemeinde Wonnegau.

Westhofen had its first documentary mention as far back as Carolingian times and was granted market rights in 1324.

Westhofen's importance in earlier times can be seen in the ring of defences around the village, which are still preserved, and which include a wall and several dykes.

The most renowned winemaking appellations – Grosse Lagen (as classified by the Verband Deutscher Prädikatsweingüter VDP) – are the Aulerde, Kirchspiel, Brunnenhäuschen and Morstein.

Westhofen is one of the places in Rhenish Hesse where mammalian remains from some ten million years ago have been found, in the prehistoric Rhine’s Deinotherium Sands, whose name comes from this extinct proboscid’s teeth and bone remnants, which are often yielded up by these deposits.