It relocated to Maurice A. Ferré Park in the downtown area adjacent to the Perez Art Museum Miami in 2017 after the closing of the Coconut Grove location in 2015.

[3] The exhibits were made up of donated items, such as a hive of live honeybees which hung outside a window, and loaned materials, such as Seminole artifacts from the University of Florida.

[2] In 1952, the museum relocated to a larger space in the Miami Women's Club building on North Bayshore Drive.

[6] The Planetarium was the home of the national astronomy television show Star Gazers with Jack Horkheimer, produced by Miami's PBS member station WPBT.

[15][16] Sitting on four acres (1.6 ha), the new LEED Gold-certified complex consists of four interconnected buildings with parking underneath: As of June 15, 2023 the former site of the Miami Science Museum and Space Transit Planetarium has been demolished to make way for the Vizcaya Village project.

The bottom-most level exhibits the Gulf Stream Aquarium where drifters such as jellyfish ride the massive flow running along Florida's east coast and into the North Atlantic.

The Frost Planetarium seats 250 people and features six 16-million-color 8K projectors, surround sound, and a 67-foot wide dome screen tilted forward at 23.5°.

Feathers to the Stars exhibits the history of flight from animals utilizing wings, to humans creating airplanes and spacecraft.

[24] meLab is an interactive exhibit focused on health and well being, highlighting the importance of making good choices for better long-term outcomes.

The exhibit consists of two spaces: an outdoor hands-on area, and an indoor virtual Everglades where animal characters interact with guests and teach them about concepts such as biodiversity using stories.