Michael Peter Kaye (died December 17, 2017) was an American surgeon and researcher who co-founded the International Society for Heart and Lung Transplantation (ISHLT) in 1981.

Kaye was the first director of the ISHLT's International Database for Heart and Lung Transplantation, which became the largest registry of its kind in the world.

[1] In the mid-1970s, Kaye devised a new heart surgery for transposition of the great arteries, and two other surgeons (Paul Damus and Horace Stansel) independently proposed similar operations around the same time.

[2] In the 1980s, he became Professor of Surgery and head of the cardiothoracic research laboratories at the University of Minnesota, where he continued his work on heart and lung transplantation.

[1][8] In 1996, Kaye received the ISHLT lifetime service award[9] and in 1997, he co-founded Acumen Healthcare Solutions, a clinical trials software company.