The A. Vassiliadis Family Pavilion for Advanced Surgery includes intraoperative MRI machines and the only Restrictive Spectrum Imaging facility in the United States.

The Pauline and Stanley Foster Pavilion for Cancer Care houses a blood and marrow transplant program jointly operated by UC San Diego Health and Sharp Healthcare, the floor for which is completely pressurized and filtered allowing patients to roam freely.

[5] Each of the hospital's private rooms is equipped with an Apple iPad for controlling lighting, checking medical records, and contacting care providers.

East Campus Medical Center at UC San Diego Health was purchased from Prime Healthcare Services on December 12, 2023.

It aims to provide enhanced emergency care units, as well as access to a wider variety of behavioral health and psychiatry services.

The Sulpizio Family Cardiovascular Center provides ambulatory, clinical, and inpatient heart and stroke care in one central location.

Sulpizio Cardiovascular Center is the region's first academic-based facility to combine all heart and vascular-related services, programs and technology under one roof.

[citation needed] It is connected by footbridges to Jacobs Medical Center and the Altman Clinical and Translational Research Institute, a 311,000 gross square feet, $269 million laboratory building.

[11] Several pioneering medical innovations have been made by UC San Diego researchers, such as the development of the chemotherapy drug cetuximab, the use of gene therapy in the treatment of congenital defects, the discovery of insulin resistance as a cause of diabetes, the understanding of genetic blood disorders such as sickle cell disease, the link between vitamin D deficiency and certain cancers, the first human trials of robotically assisted laparoscopic surgery, the development of the first oral drug for treating interstitial cystitis called Elmiron, the demonstration of HIV latency, the link between the p53 gene and rheumatoid arthritis, the identification of the genetic basis for familial cold autoinflammatory syndrome, the discovery of an early warning sign for autism, the connection between inflammation and cancer, the use of green fluorescent protein as a surgical and research aid, the nation's first sleeve gastrectomy, and the discovery of a potential treatment for chronic lymphomatic leukemia called Cirmtuzumab.

Under the terms of this agreement, ECRMC patients have access to specialized facilities operated by UC San Diego Health in the city.

[17] UC San Diego Health participates in a similar program with the Tri-City Medical Center community hospital in Oceanside.

It is housed in a building adjacent to Salk, UC San Diego, and Torrey Pines Gliderport and performs basic and preclinical stem cell and regenerative medicine research.

The facility includes eight surgery suites, basic and advanced imaging, physical therapy and pain management, as well as infusion and apheresis services.

[23] UC San Diego Health was also in the process of approving a joint powers agreement with Tri-City Medical Center in North County to add to their network of hospitals.