Thrush starred in the Palme d'Or and César award-nominated film Jimmy P: Psychotherapy of a Plains Indian.
Thrush, who is Cree, was born and raised in Calgary, Alberta, Canada,[1] by parents who were chronic alcoholics.
Commenting on her experience at that school, she stated: "There were other Native students there, and I learned so many wonderful things about myself, about my culture, about my language, about drumming and singing.
[2] She portrayed numerous recurring and guest roles in the television series Madison, Northern Exposure, North of 60, Highlander, Forever Knight, Nothing Too Good for a Cowboy, Moccasin Flats and Mixed Blessings.
These include Isaac Littlefeathers, Unnatural & Accidental, Bury My Heart at Wounded Knee, Skins, Dead Man, Dreamkeeper and Jimmy P: Psychotherapy of a Plains Indian.