Higginson was born in Burlington, Ontario and studied to become an actor at the Guildhall School of Music and Drama in London, United Kingdom.

Higginson took over the role of Elizabeth Weir from Jessica Steen in a guest spot on the season eight opener of Stargate SG-1.

In 2015, Higginson was cast in the CBC Television drama series This Life as Natalie Lawson, a lifestyle columnist and single mother who is diagnosed with terminal cancer.

[5] In February 2021, it was announced that Higginson, who had a recurring role on the CTV medical series Transplant, was upgraded to a regular cast member for season 2 after the rights for the show were acquired by NBC.

[6] Higginson won a Gemini Award for Best Performance by an Actress in a Continuing Leading Dramatic Role for The City in 2000.