This electron-rich derivative of benzophenone is an intermediate in the production of dyes and pigments, for example Methyl violet.

The ketone is prepared today as it was originally by Michler using the Friedel-Crafts acylation of dimethylaniline (C6H5NMe2) using phosgene (COCl2) or equivalent reagents such as triphosgene[3] The related tetraethyl compound (Et2NC6H4)2CO, also a precursor to dyes, is prepared similarly.

Michler's ketone is an intermediate in the synthesis of dyes and pigments for paper, textiles, and leather.

Michler's ketone is commonly used as an additive in dyes and pigments as a sensitizer for photoreactions because of its absorption properties.

Specifically Michler's ketone absorbs intensely at 366 nm and effectively sensitizes photochemical reactions such as the dimerization of butadiene to give 1,2-divinylcyclobutane.