Microsporum audouinii

[4] However, there are other factors that can influence its growth, such as pH, relative humidity, organic carbon, nitrogen and temperature.

[4] Microsporum audouinii appears to prefer a neutral pH in the range of 6.8-7.0 and room temperature for growth.

[5] Microsporum audouinii is effective in utilizing its carbon sources, but growth is strongest in the hexoses (glucose, mannose and fructose) and weakest in maltose, sucrose, lactose and galactose.

[5] It is unable to synthesize the vitamins thiamine, niacin and riboflavin and requires an exogenous supply of these materials to support its growth.

[2] These superficial dermal diseases are generally found in prepubescent children (starting at 6 months) and rarely affect adults.

Differences in the chemical composition and quantity of the triglycerides in hair sebum secreted are the primary reasons.

[7] In addition, increased sweat production as well as the presence of Malassezia furfur decreases the ability for M. audouinii to thrive.

[9] In most cases of adult onset Tinea capitis due to M. audouinii, there is at least one predisposing factor such as immunocompromise (e.g., diabetes mellitus, systemic lupus, organ transplant and HIV), a local animal reservoir (e.g., infected pet or farm animal) and hormonal changes in postmenopausal women.

[7] Eventually due to mechanical forces (the movement of the fungi) and keratinase (a chymotrypsin-like enzyme with optimal activity at an acidic pH), all but 1–2 mm of the diseased hair follicle weakens and falls off.

Direct microscopy with 10% KOH would show small to medium conidia with ectothrix hair invasion.

[17] Currently, squalamine, an aminosterol with fungicidal properties is being researched as its mechanism of action is different from that of the aforementioned medicines, making it a good drug for those who don't respond well to itraconazole, fluconazole, or terbinafine.

Topical ointments immobilize the fungus and reduce shedding but they do not penetrate the hair follicle and hence must be used in conjunction with other treatment methods.