Mifflinville is an unincorporated community and census-designated place (CDP) in Columbia County, Pennsylvania, United States.

Mifflinville is located in east-central Columbia County at 41°1′43″N 76°18′26″W / 41.02861°N 76.30722°W / 41.02861; -76.30722 (41.028617, -76.307175),[5] in the northern part of Mifflin Township.

[6] Mifflinville is on the south side of the Susquehanna River, several miles downriver (southwest) from Berwick.

The eastern part of Mifflinville is mostly farmland, while the western section is residential.

[7] Interstate 80 passes just southwest of Mifflinville, with access from Exit 242 (Pennsylvania Route 339).

Bloomsburg, the Columbia County seat, is 9 miles (14 km) to the west via either I-80 or U.S. Route 11.