Milburn is an unincorporated community in Carlisle County, Kentucky, United States.

[2] Located along Kentucky Route 80 at its junction with Kentucky Routes 1371 and 1377, Milburn lies amid rolling countryside at the headwaters of Guess Creek, a tributary of Bayou du Chien; the nearest point on the Mississippi River is approximately 12 miles (19 km) to the west.

Nearby cities include Arlington, 6 miles (9.7 km) by air to the west, and Bardwell, 8 miles (13 km) by air to the northwest; Milburn is connected to them by Kentucky Route 80 and Kentucky Route 1377 respectively.

A state hunting preserve, the Obion Creek Wildlife Management Area, lies 2 miles (3.2 km) to the south.

[3] A fire station is located in Milburn,[4] and a Creole cottage in the community, the George W. Stone House, is listed on the National Register of Historic Places.