[4][5] The most common presentation of Milroy's disease is unilateral lower extremity lymphedema, and may also be accompanied by hydrocele.

Males and females may have upslanting toenails, deep creases in the toes, wart-like growths (papillomas), and prominent leg veins.

Some individuals develop non-contagious skin infections called cellulitis that can damage the thin tubes that carry lymph fluid (lymphatic vessels).

May have similar health conditions, delays, disorders, and physical traits associated with other lymphatic genetic diseases and chromosome #5 abnormalities.

[10] Medscape states patients may have recurrent streptococcal cellulitis and lymphangitis, with subsequent hospitalizations for antibiotic therapy.