Splenectomy may be warranted for persistent pseudocysts due to the high risk of subsequent rupture.

[5][6][7] There is no specific treatment, except treating the underlying disorder and providing adequate pain relief.

These emboligenic disorders include atrial fibrillation, patent foramen ovale, endocarditis or cholesterol embolism.

In sickle cell disease, repeated splenic infarctions lead to a non-functional spleen (autosplenectomy).

Various other conditions have been associated with splenic infarction in case reports, for example granulomatosis with polyangiitis[15] or treatment with medications that predispose to vasospasm or blood clot formation, such as vasoconstrictors used to treat esophageal varices, sumatriptan[16] or bevacizumab.

[17] In a single-center retrospective cases review, people who were admitted to the hospital with a confirmed diagnosis of acute splenic infarction, cardiogenic emboli was the dominant etiology followed by atrial fibrillation, autoimmune disease, associated infection, and hematological malignancy.