Mindjedef (born c. 2575 BC[1]) was a Prince of ancient Egypt, who lived during the 4th Dynasty.

Mindjedef was a son of Crown Prince Kawab and Queen consort Hetepheres II.

Mindjedef was a brother of Queen Meresankh III and uncle of Princes Rawer and Minkhaf II.

It is known that Mindjedef had a wife called Khufuankh ("Khufu lives").

Mindjedef and Khufuankh are depicted with a small son in the chapel, but his name is not preserved.