Minnesota State Highway 220 (MN 220) is a 78.536-mile-long (126.391 km) regional trunk highway in northwest Minnesota, which runs from its intersection with U.S. Highway 75 in Climax and continues north to its northern terminus at its intersection with MN 11 near Drayton, North Dakota.

For part of its route (4 miles), MN 220 runs together with U.S. Highway 2 in the city of East Grand Forks.

Highway 220 serves as a north–south route in northwest Minnesota between Climax, East Grand Forks, Alvarado, Oslo, and Robbin.

Red River State Recreation Area is located in the city of East Grand Forks near the junction of Highway 220 and U.S. Highway 2.

[1] It originally intersected U.S. 75 near Eldred and followed present-day County State-Aid Highway 45 to its current routing.