[4] It is also home to several community centers, several neighborhood groups, one branch of the Boston Public Library, one high school, and one newspaper.

On Tremont Street is Our Lady of Perpetual Help Basilica (1878, Schickel and Ditmars, 1910 towers addition by Franz Joseph Untersee),[8] an eponymous landmark building that dominates the skyline of the area.

Due to these adjacencies, the neighborhood is often struggling with institutional growth taking residential buildings and occupying storefront commercial space.

The Mission Hill Triangle is an architectural conservation district with a combination of freestanding houses built by early wealthy landowners, blocks of traditional brick rowhouses, and many triple-deckers.

The neighborhood was named in March 2008 as one of 25 "Best ZIP Codes in Massachusetts" by The Boston Globe, citing increased value in single-family homes, plentiful restaurants and shopping, a marked racial diversity, and the behavioral fact that 65% of residents walk, bike, or take public transit to their work.

The walkway is lined with benches for people to rest and enjoy the various views such as Lower Roxbury, the Fenway, and Back Bay.

The majority of government, commercial, and institutional entities list "Mission Hill" in the breakdown of Boston neighborhoods and its boundaries generally agreed upon.

The lower portion of the eastern hill was a puddingstone quarry with large swaths owned by merchants Franklin G. Dexter, Warren Fisher, and Fredrick Ames.

Huntington Avenue, now one of the main connections to the rest of Boston, once stopped at the intersection of Parker Street, near the present-day site of the Museum of Fine Arts.

The once main intersection of Parker Street and Huntington Avenue has been traffic-engineered, cutting the straight-line road in two and forcing traffic to first turn onto Forsyth Way to make the connection.

By the 1870s beer production was the main industry in Mission Hill, and many breweries lined the Stony Brook (now a culvert running along the Southwest Corridor).

After the 1880s and the re-routing of the Muddy River by Frederick Law Olmsted, Huntington Avenue was joined from Parker Street to Brigham Circle, creating the Triangle District.

In 1870, the Redemptorist Fathers built a humble wooden mission church that was replaced by an impressive Roxbury puddingstone structure in 1876.

At one time, the Basilica was a campus of buildings; the Queen Anne style Sister's Convent and Grammar School (1888–1889, Henry Burns) and the Romanesque Revival St. Alphonsus Hall (1898, Franz Joseph Untersee) administered by the parish.

It was the preeminent social and athletic Catholic men's organization for nearly 50 years and its 1000-seat theatre held many community, political, and theatrical events.

Another example of high religious architecture is the Annunciation Greek Orthodox Cathedral of New England at 514 Parker Street at the eastern edge of the neighborhood.

Built between 1892 and 1927, it is one of the oldest Greek churches in the United States, a Boston landmark, and is listed on the National Register of Historic Places.

The radiant stained glass windows and large crystal chandeliers also contribute to the visual majesty of the cathedral's interior.

The carpenter-contractor John Cantwell lived in the Gothic Revival cottage at 139 Hillside Street, and purchased the Hoxie House after Timothy's death.

Calumet, Iroquois and other streets with Native American names were built up within ten years into a dense neighborhood of triple deckers in the Queen Anne style.

In the late 19th century through the 1970s, the neighborhood was once home to large numbers of families of recent immigrant descent: mostly Irish, but also Germans, Italians, and others.

The original thirty-eight 3-story brick structures built between 1938 and 1940 were demolished in the mid-1990s and replaced with 535 new apartments with a mix of subsidized and market-rate units.

When Gordon moved out of the neighborhood near the Museum of Fine Arts and relocated to Wenham, Massachusetts, Wentworth Institute of Technology bought the land.

[26] In the late 1960s, Harvard University, through straws, thus concealing the purchases from the neighborhood, bought the wood frame and brick houses along Francis, Fenwood, St. Alban's, Kempton Streets, and part of Huntington Avenue, and announced plans to demolish the buildings.

In 1962, the Mission Hill public housing development had 1,024 families (all white), while the Mission Hill Extension project across the street had 580 families (of which 500 were black), and in 1967 when the Boston city government under Mayor John F. Collins (1960–1968) agreed to desegregate the developments, the projects were still 97 percent white and 98 percent black respectively.

Ten years later saw the creation of the Southwest Corridor, a park system with bike and pedestrian trails that lead into the center of Boston.

In 2020, Boston was reported to be the third most "intensely gentrified" city in the United States, listing Mission Hill as one neighborhood undergoing gentrification.

[32] World class teaching hospitals are found in the adjacent Longwood Medical Area, which is sometimes treated administratively by the city as part of the Mission Hill neighborhood.

A community relations function of Brigham and Women's hospital supports the Mission Hill community, addressing issues of health care, employment, social programs, and services through outreach to schools, housing developments, youth-serving organizations, and other service groups in Mission Hill and elsewhere in Boston.

Also adjacent to Mission Hill/Longwood are the Colleges of the Fenway, Wentworth Institute, Northeastern University, and the School of the Museum of Fine Arts.