The road continues eastward across northern Tate County and ends at MS 305 near Independence.

[6] MS 304 Scenic and MS 306 travel eastward across the northern part of the town, crossing over the Illinois Central Railroad in a forested area,[6][5] and it intersects I-55 at a diamond interchange (Exit 271) east of Hill Road.

Surrounded by farmland,[5] MS 306 leaves the corporate limits of Coldwater east of Hardin Road.

[3] In January 1952, the first construction projects of the year were announced by the Mississippi State Highway Department.

One project was MS 306, which included grading, drainage and culverts, and gravel surfacing.