It is planned to travel from US Highway 90 (US 90) near the Port of Gulfport to I-10.

Officials want the highway to be as close as possible to the port so it can be accessed easily.

[1] The highway's designation was at first considered to be I-210, but, because the Interstate is going to the port and not going to connect back to I-10 forming a loop, the road was numbered I-310; I-110 was already taken in nearby Biloxi.

The design of the highway began in 2005 and the right-of-way acquisitions started in 2006.

[citation needed] When the Infrastructure Investment and Jobs Act designated an extended future I-14 corridor that would encompass the original "14th Amendment Highway" and "Gulf Coast Strategic Highway" concepts, future I-310/MS 601 became part of the High Priority Corridor 100, the Central Mississippi Corridor, part B.