Its southern terminus was at MS 43, which is now inside the John C. Stennis Space Center.

As of 1965, the route was located in northwestern Hancock and southern Pearl River counties.

About two miles (3.2 km) north of the southern terminus, MS 602 intersected Texas Flat Road.

The road then crossed over Dead Tiger Creek, and shifted back slightly to the west.

It intersected Lott McCarty Road before entering Pearl River County.