The road then continues through rural New Madrid County and ends at a boat ramp near the Mississippi River.

In 2015, Missouri Department of Transportation (MoDOT) calculated as many as 1,888 vehicles traveling on Route 162 west of Route 153, and as few as 252 vehicles traveling east of Route M. This is expressed in terms of annual average daily traffic (AADT), a measure of traffic volume for any average day of the year.

At Fourth Street, Route 162 travels eastward, ending the concurrency.

[1] The route passes by the entrance of the Gideon Memorial Airport, before leaving the city at County Road 279 (CRD 279).

The road travels across the northern part of the city, intersecting city streets and Route F. After crossing over the River Subdivision railroad, the road meets US 61 at a T-intersection and becomes concurrent.

East of CRD 427, the road intersects the termini of Routes KK and TT.