Mistretta (Sicilian: Mistritta) is a comune (municipality) in the Metropolitan City of Messina in the Italian region Sicily, located about 90 kilometres (56 mi) east of Palermo and about 110 kilometres (68 mi) west of Messina.

Mistretta borders the following municipalities: Capizzi, Caronia, Castel di Lucio, Cerami, Nicosia, Pettineo, Reitano, Santo Stefano di Camastra.

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