It originates in Phop Phra District, Tak Province, flowing then from south to north across Mae Sot, Mae Ramat, and Tha Song Yang Districts, finally entering the Salween River within the limits of Sop Moei District of Mae Hong Son Province.

The Yuam River joins its left bank only 7 kilometres (4 mi) before its confluence with the Salween.

Many fish species inhabit its waters, including the giant river catfish.

[2] Often Karen people cross the river either in order to enter Thailand as refugees or to go back to Burma.

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