The stream headwaters are in western Moniteau County just west of Tipton.
The stream continues meandering east passing under Missouri Route 87 south of Jamestown and enters the Missouri River floodplain in the Marion Bottoms Conservation Area between Sandy Hook to the north and Marion to the south.
The confluence with the Missouri River floodplain lies in the northern tip of Cole County.
[1] Moniteau Creek derives its name from the Indian term Manitou.
This article related to a river in Missouri is a stub.