These cytokines induce the activation of transcription factors which push completion of the monoblast's myeloid cell fate.

Macrophages can produce a variety of effector molecules that initiate local, systemic inflammatory responses.

These monoblast differentiated cells are equipped to fight off foreign invaders using pattern recognition receptors to detect antigen as part of the innate immune response.

[1] A typical monoblast is about 12 to 20 μm in diameter, has a nuclear to cytoplasm ratio of 4:1 to 3:1, and, like most myeloid blasts, has a round to oval nucleus with fine chromatin structure.

[8] Hematopoietic stem cells mature into monoblasts by being in a concentrated environment of certain cytokines that induce activation of certain transcription factors.