Highway 25's western terminus is at U.S. Route 2 in Wolf Point, Montana.

After bending southeastward, it passes the Lyman Clayton Airport and the Airport Golf Club, ending at Montana Highway 13, just to the north of the Missouri River.

[2] During the 1930s, an old alignment of Highway 25 existed from Lewistown to Billings.

[citation needed] The entire route is in Roosevelt County.

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