Mormoiron (French pronunciation: [mɔʁmwaʁɔ̃]; Occitan: Mormeiron) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in Southeastern France.

Mormoiron is located 12 km East of Carpentras; also nearby are Mont Ventoux and Avignon.

The commune's area was occupied prehistorically (approximately 100,000 BC), as is evidenced by the discovery of bifaces and Pottery.

Evidence from the twenty-first century BC points to trade relations with Phocaea and ancient Marseille.

Roman colonization left behind altars to Mercury, coins from the Augustan and Trojan reigns, and various other artefacts.