Gueron played a central role in developing global medicine, and he is mainly known for his work on the treatment of heart patients with cardiovascular manifestations of severe scorpion sting.

There he met his future colleagues and past friends from Bulgaria: Prof. Pascal Tiberin, Prof. Menachem Hirsch, Prof. Isaac (Izzy) Djerassi, a Philadelphia-based medical researcher and clinician in the fields of hematology and oncology,[4] and Prof. Joseph Rosenfeld.

Prof. Yosef Stern, Soroka's first director general supported Gueron's idea to establish a department of cardiology in the hospital.

This issue has evolved into a large-scale, great depth research by Prof. Gueron and his team, who were the first in the field of medicine to have found that yellow scorpion venom evokes potent cardiovascular responses in humans.

[2] Gueron's work, his treatments in patients and studies on severity of scorpion stings were published in the largest medical publications on a global scale.

[3][6][1] Gueron was appointed Professor at Soroka Medical Center in 1967, and was involved in the development of the techniques of heart and heart-lung treatment.

Gueron's research has shown that thirty-four patients with severe scorpion sting were reviewed and pertinent data related to the cardiovascular system such as hypertension, peripheral vascular collapse, congestive heart failure or pulmonary edema were analyzed.

Gueron was questioned regarding the value of giving antivenin, and he replied that although it is freely available, all cases of scorpion sting are treated without it, and there had not been a single fatality in 1989.